Fixotic advance with fipronil, s-methoprene ectoparasiticide from Vetoquinol help eliminate/kill adults as well as larva of fleas, tick ,mites in dogs & puppies. Effective for 1 whole month. Active IGR property, acts on all life stages, long-lasting, fast-acting. Like all spotons, to apply this, remove fur with hand so skin can be seen, apply directly on to the skin along the upper side of the neck. The solution then spreads through the epithelial layer of the skin.